#271 New Orleans
#272 San Francisco

Sunday November 27, 2022
at 4:25pm EST

8 Free Predictions

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A pair of former NFC West rivals clash on the gridiron in the city by the bay hoping to pick up a victory. The New Orleans Saints are on the road as they make the cross-country trip to face the San Francisco 49ers Sunday afternoon. New Orleans comes in off a 27-20 home victory over the Rams, covering the line as a 2.5-point favorite, in their previous contest last Saturday. San Francisco earned a one-sided 38-10 victory over Arizona in a game held in Mexico City on Monday Night Football in their... Read more



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The San Francisco 49ers (6-4, 3-1 Home) will host the New Orleans Saints (4-7, 1-3 Away) in Santa Clara, CA at Levi's Stadium. The 49ers are coming from a dominating win over the Arizona Cardinals last week while the Saints are coming from a big win over the Los Angeles Rams. Enter this matchup, the 49ers are 9.5-point favorites. Saints Looking for Huge Road Win Against 49ersThe New Orleans Saints have been pretty inconsistent this season, playing competitively in some games and weak in other ga... Read more



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New Orleans Saints at San Francisco 49ers 11/27/22 - NFL Picks & Predictions TJ Tue, 11/22/2022 - 19:54 The San Francisco 49ers head home on Sunday and will host the New Orleans Saints. The 49ers are 6-4 on the season and tied for the top of the NFC West. San Francisco is riding a three game win streak heading into Week 12 of action. The 49ers are allowing 305 yards per game which is 1st in the NFL. The San Francisco 49ers scored 38 points on Monday Night Football in their win at Arizona. Tight... Read more



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Jimmy Garoppolo wasn't the San Francisco 49ers starting quarterback when the season began. Read more



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Our NFL experts predict, pick and preview the New Orleans Saints vs. San Francisco 49ers game, with kickoff time, TV channel and spread. Read more



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The New Orleans Saints and the San Francisco 49ers meet Sunday in NFL action from Levi’s Stadium. New Orleans is 4-7 this year and coming off a win over the Rams. As for San Francisco, they played Arizona on Monday. In that game the 49ers posted a blowout win. Check back all season long for … Read the rest of "San Francisco 49ers vs New Orleans Saints 11/27/22 NFL Picks, Predictions, Odds" at Sports Chat Place Read more



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San Francisco 49ers (6-4) vs New Orleans Saints (4-7) Game Info: Sunday, November 27, 2022 at 4:25 pm (Levi's Stadium) Betting Odds: San Francisco 49ers -8.5 -- Over/Under: 43 Click Here for the Latest Odds Where to Watch: Fox Stream live sports and exclusive originals on ESPN+. Sign up now! The New Orleans Saints will play the San Francisco 49ers on Sunday afternoon at Levi’s Stadium in Santa Clara, California. The New Orleans Saints are 4-7 this season after they defeated the Los Angeles Rams... Read more