#109 Buffalo
#110 New Orleans

Thursday November 25, 2021
at 8:20pm EST

7 Free Predictions

We searched the web and found all of the free predictions available for this game.



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Buffalo will try to re-establish itself as the top team in the AFC when it travels to New Orleans for a Thanksgiving Day matchup on Thursday night. The Bills have lost two of their last three games and are now just two games above .500. New Orleans is on a three-game losing skid and has fallen out of the playoff picture. Bills trying to avoid another upset lossBuffalo appeared to be the team to beat in the AFC when it got off to a 4-1 start this season, including a blowout win at Kansas City. Th... Read more



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The Buffalo Bills travel to the Caesars Superdome for a Thanksgiving showdown with the New Orleans Saints on Thursday evening. The Bills (6-4) were destroyed by the Indianapolis Colts 41-15 in their last game and will look for a much better defensive effort. The Saints (5-5) had defensive issues of their own in a 40-29 loss to the Philadelphia Eagles on Sunday. Both teams will look for consistency in a short week. Buffalo opens this game as 4.5 point road favorites. Bills Trounced by ColtsThe Bi... Read more



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The Buffalo Bills and New Orleans Saints meet Thursday in week 12 NFL action at Caesars Superdome. The Buffalo Bills look for a win after splitting their last six games. The New Orleans Saints look to snap a three-game losing streak. The Buffalo Bills have won three of their last five road games. Josh Allen … Read the rest of "New Orleans Saints vs Buffalo Bills 11/25/21 NFL Picks, Best Bets and Odds" at Sports Chat Place Read more



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Our NFL experts predict, pick and preview the Buffalo Bills vs. New Orleans Saints Thanksgiving game, with kickoff time, TV channel and spread. Read more



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Building a same-game parlay for Bills vs. Saints? Our NFL betting analyst makes his picks on PointsBet for this Thanksgiving showdown. Read more



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New Orleans Saints (5-5) vs Buffalo Bills (6-4) Game Info: Thursday, November 25, 2021 at 8:20 pm (Caesars Superdome) Betting Odds: New Orleans Saints +6 -- Over/Under: 45.5 Click Here for the Latest Odds Where to Watch: NBC Stream live sports and exclusive originals on ESPN+. Sign up now! The Buffalo Bills and New Orleans Saints face off in an NFL showdown on Thanksgiving night at the Mercedes-Benz Superdome. When these two teams faced off in 2017, the Saints came away with the 27-10 victory. ... Read more



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