#115 Clemson University
#116 Syracuse University

Friday October 15, 2021
at 7:00pm EDT

5 Free Predictions

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The Syracuse Orange hope to throw another monkey wrench in the slumping season of the Clemson Tigers on Friday night. Another heartbreaking loss last week now has the Orange sitting at an even 3-3 coming in against a Tigers team fresh off a bye week. Syracuse has lost by three points in back-to-back games with Wake Forest and Florida State. Now, they face the challenge of trying to survive as double-digit underdogs against the visiting Tigers. Can the Tigers be trusted?Quarterback D.J. Uiagalele... Read more



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The Clemson Tigers will be going for their second consecutive win when they face the Syracuse Orange on Friday night. The Tigers are coming off a 19-13 win over Boston College as 14.5-point favorites. The Orange are coming off a 40-37 loss to Wake Forest as six-point underdogs. Clemson is 7-2 in nine games against Syracuse. Tigers Going For Fourth Win In Six GamesThe Tigers bounced back from their loss to NC State with a win over previously unbeaten Boston College. They will try to keep the mome... Read more



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Clemson vs. Syracuse Odds Clemson Odds -13.5 (-110) Syracuse Odds +13.5 (-110) Moneyline -575 / +410 Over/Under 45 (-110 / -110) Time 7 p.m. ET TV ESPN Odds Read more



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Syracuse Orange (3-3) vs Clemson Tigers (3-2) Game Info: Friday, October 15, 2021 at 7:00 pm (Carrier Dome) Betting Odds: Syracuse Orange +13.5 -- Over/Under: 45 Click Here for the Latest Odds Where to Watch: ESPN Stream live sports and exclusive originals on ESPN+. Sign up now! The Clemson Tigers and Syracuse Orange face off on Friday in an ACC college football showdown at the Carrier Dome. The last time these two teams faced off in 2020, Clemson won 47-21.  Coming into the season the dreams fo... Read more



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