It may be a monochromatic matchup, but this Syracuse vs. Clemson prediction highlights the ACC's marquee showdown on Wednesday night. South Carolina's Littlejohn Coliseum will host the 7:00 p.m. EST clash. These schools met twice last year, with the Clemson Tigers (15-4; 11-8-0 ATS) sweeping the Syracuse Orange (9-9; 7-10-1 ATS) easily. Will the Tigers strike again in their only scheduled 2025 meeting? Nobody does it better when it comes to NCAAB Picks! Syracuse Securing VictoriesThe Orange (3-4... Read more

It’ll be a brawl in the ACC as the 15-4 Clemson Tigers host the 9-9 Syracuse Orange on Wednesday, and we have the coverage for you in this Syracuse vs. Clemson Tigers prediction. The Orange has turned it up in the ACC, winning three of their last four, while Clemson remains resilient, winning two consecutive road tilts and three in a row overall. Read on for a summary of this game and a conclusion on the side and total. You can also check out additional Wednesday games on the free picks page. Ga... Read more

Get our free College Basketball betting pick for the Clemson vs Syracuse matchup and gain an edge as a College Basketball bettor. Read more

Clemson (15-4) vs Syracuse (9-9) Game Info: Wednesday, January 22, 2025 at 7:00 pm (Littlejohn Coliseum) Betting Odds: Clemson -15.5 -- Over/Under: 143.5 Click Here for the Latest Odds Where to Watch: ACC Network The Syracuse Orange are visiting the Clemson Tigers on Wednesday, January 22nd at the Littlejohn Coliseum. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Syracuse Orange vs Clemson Tigers Prediction. We will examine: The Clemson Tiger... Read more