San Francisco Giants (44-36) vs. Chicago White Sox (26-55)  The 2025 MLB betting action goes on Friday, June 27, with the San Francisco Giants squaring off against the Chicago White Sox in the interleague showdown at Rate Field in Chicago, Illinois, and we’ve got you covered with our Giants vs. White Sox prediction.  San Francisco and Chicago open their three-game regular-season series, and the Giants are -165 moneyline favorites with a total of 8.5 runs. Last year, the Giants took two out of th... Read more

An interleague matchup goes down on Friday, June 27 as the San Francisco Giants take on the Chicago White Sox at 7:40 p.m. ET, so continue reading for our Giants vs White Sox prediction. This is written before Thursday's game has ended. Don’t go down on strikes! Get our top Free MLB Picks and increase your bankroll! Giants Battling for Wild Card SpotSan Francisco is 44-36 and is third in the NL West entering play on Thursday, after losing the first two games of the series against the Marlins, th... Read more

Get our free Baseball betting pick for the Chicago White Sox vs San Francisco Giants matchup and gain an edge as a Baseball bettor. Read more