Philadelphia Phillies (47-31) vs. Houston Astros (45-33)  The MLB betting action continues Wednesday, June 25, with the Philadelphia Phillies taking on the Houston Astros in the interleague showdown at Daikin Park in Houston, Texas, and we’ve prepared the best Phillies vs. Astros prediction along with the latest odds update.  Philadelphia and Houston continue their three-game regular-season series, and Tuesday’s opener has been excluded from this preview. The Phillies are -145 moneyline favorite... Read more

An interleague matchup goes down on Wednesday, June 25, at 8:10 p.m. ET as the Philadelphia Phillies take on the Houston Astros, so continue reading for our Phillies vs Astros prediction. This is written before Tuesday's game has ended. When it comes to baseball picks, our MLB Predictions are stellar. Phillies Starting WheelerPhiladelphia enters play on Tuesday with a record of 47-31, which is first in the NL East. The Phillies are hitting .258, which ranks second, while on the road are hitting... Read more

Get our free Baseball betting pick for the Houston Astros vs Philadelphia Phillies matchup and gain an edge as a Baseball bettor. Read more

The Philadelphia Phillies are -150 favorites vs the Houston Astros Philadelphia Phillies vs Houston Astros Over / Under today: 7.5 Runs Philadelphia Phillies / Houston Astros TV Channel: NSPA | SCHN | SCH2 The Philadelphia Phillies (-150) visit Daikin Park to take on the Houston Astros (+125) on Wednesday, June 25, 2025. First pitch is scheduled for 8:10pm EDT in Houston, TX, TX. This season, the Philadelphia Phillies are 47-32 against the spread (ATS), while the Houston Astros are 40-39 ATS. Ph... Read more