It’s a battle between neighboring states for a mid-week clash starting Tuesday, June 17. Read our St. Louis Cardinals vs Chicago White Sox prediction along with our other MLB picks. The Cardinals are 37-35 and they are just a few games back of the wild card. The White Sox are 23-49 and they have the worst record in the American League. Both teams have struggled for wins with the Cardinals losing seven of their last eight games. The White Sox have lost five straight. The Cardinals are starting Ma... Read more

In our Cardinals vs. White Sox prediction, the St. Louis Cardinals are fourth in the NL Central with a 37-35 record so far. They are having young left-hander Matthew Liberatore get the start as he is coming off a loss against the Toronto Blue Jays where he allowed five runs on nine hits with one walk and four strikeouts in 5.0 innings of work.    The Chicago White Sox are looking to improve as they are sitting in fifth place in the AL Central with a 23-49 record entering this game. Young ri... Read more

Get our free Baseball betting pick for the Chicago White Sox vs St. Louis Cardinals matchup and gain an edge as a Baseball bettor. Read more

The Cardinals are -150 favorites vs the White Sox Cardinals vs White Sox Over / Under today: 8 Runs Cardinals / White Sox TV Channel: FDMW | CHSN The St. Louis Cardinals (-150) visit Rate Field to take on the Chicago White Sox (+125) on Tuesday, June 17, 2025. First pitch is scheduled for 7:40pm EDT in Chicago, IL. This season, the Cardinals are 37-35 against the spread (ATS), while the White Sox are 42-30 ATS. Cardinals vs White Sox Starting Pitchers Today: Cardinals starting pitcher: Matthew L... Read more