We have an Interleague series on Tuesday night featuring this Guardians vs. Giants prediction. This is the opening game of the series as these teams met last season with Cleveland taking two of three at home. The opening pitch is expected to take place at 9:45pmET from Oracle Park. Read on for more on this Guardians vs. Giants prediction and get our top MLB Betting Picks to increase your bankroll! Guardians are strugglingCleveland is now .500 at 35-35 after losing three straight at Seattle over... Read more

In the opener of an interleague series in the City by the Bay the Giants (41-31) play host to the Guardians (35-35). San Fran has lost two in a row and three of four games and Cleveland has lost three in a row. Keep reading this Cleveland Guardians vs. San Francisco Giants prediction to get the full score info, pitching matchup, and other free MLB picks. The hometown Giants are pretty big favorites in Game 1 of this series posted at -165 with the Guardians at +140 and a total of 7 runs. Guardian... Read more

Get our free Baseball betting pick for the San Francisco Giants vs Cleveland Guardians matchup and gain an edge as a Baseball bettor. Read more

The Giants are -160 favorites vs the Guardians Guardians vs Giants Over / Under today: 7 Runs Guardians / Giants TV Channel: GDTV | NSBA The Cleveland Guardians (+135) visit Oracle Park to take on the San Francisco Giants (-160) on Tuesday, June 17, 2025. First pitch is scheduled for 9:45pm EDT in San Francisco, CA. This season, the Guardians are 35-35 against the spread (ATS), while the Giants are 34-38 ATS. Guardians vs Giants Starting Pitchers Today: Guardians starting pitcher: Slade Cecconi... Read more