It’s the opening game of a three-game early week interleague series on the diamond in the Steel City as the Houston Astros travel to face the Pittsburgh Pirates Tuesday night and we have you covered with our Astros vs. Pirates prediction. Houston split a four-game series with Tampa Bay at home as they won 1-0 Sunday afternoon in the series finale. Pittsburgh fell 6-4 in the rubber game of a three-game set on the road against San Diego in their previous game Sunday afternoon. Last season, the Pir... Read more

The Astros are traveling to PNC Park in Pittsburgh, Pennsylvania to face the Pirates; keep reading for our Houston versus Pirates Prediction. Houston is second in the AL West with a record of 32-27. Pittsburgh is last in the NL Central with a record of 22-38. The Astros had a 1-2 record against the Pirates in 2024. The first pitch is scheduled for 6:40 p.m. EDT. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in. Astros Lacking OffenseThe Astros are heading to Pittsburgh... Read more

Get our free Baseball betting pick for the Pittsburgh Pirates vs Houston Astros matchup and gain an edge as a Baseball bettor. Read more

Pittsburgh Pirates (22-38) vs Houston Astros (32-27) Game Info: Tuesday, June 3, 2025 at 6:40 pm (PNC Park) L. McCullers (R) vs P. Skenes (R) Betting Odds: Pittsburgh Pirates -142 / Houston Astros +120 --- Over/Under: 7.5 Click Here for the Latest Odds Where to Watch: MLB.TV The Houston Astros and Pittsburgh Pirates meet Tuesday in MLB action at PNC Park. Here’s a Houston Astros vs Pittsburgh Pirates Prediction. This article will include a Houston Astros vs Pittsburgh Pirates Pick. Houston Astro... Read more