The Cleveland Guardians (25-21) and the Detroit Tigers (32-17) start up a four game series at the top of the AL Central standings in this Guardians vs. Tigers prediction. This will be the first series between these division rivals this season. Cleveland has to finish up a series with the Twins on Wednesday, while Detroit has to finish their series in St. Louis (Note: This article was published before Wednesday's results). Cleveland is starting Slade Cecconi (5.40 ERA) while Detroit sends out Jac... Read more

A pair of American League Central contenders pair up on Thursday night and we’ll make sure you are ready for the 6:40 EST first pitch from Comerica Park with our Guardians vs. Tigers predictions. Cleveland (25-21, 3rd in A.L. Central) has lined up RHP Slade Cecconi (0-1, 5.40 ERA) to start in the series opener while host Detroit (32-17, 1st in A.L. Central) turns to RHP John Flaherty (2-5, 4.44 ERA) to get the series rolling. (This game was published prior to the conclusion of Wednesday’s games.... Read more

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Detroit Tigers (33-17) vs Cleveland Guardians (26-22) Game Info: Thursday, May 22, 2025 at 6:40 pm (Comerica Park) T. Bibee (R) vs J. Flaherty (R) Betting Odds: Detroit Tigers -135 / Cleveland Guardians +114 --- Over/Under: 8 Click Here for the Latest Odds Where to Watch: MLB.TV The Cleveland Guardians and Detroit Tigers meet Thursday in MLB action at Comerica Park. Here’s a Cleveland Guardians vs Detroit Tigers Prediction. This article will include a Cleveland Guardians vs Detroit Tigers Pick.... Read more