San Diego Padres (27-18) vs. Toronto Blue Jays (22-24)  The 2025 Major League Baseball season continues Wednesday, May 21, with the San Diego Padres squaring off against the Toronto Blue Jays in the interleague battle at Rogers Centre in Toronto, ON, so we have prepared the Padres vs. Blue Jays prediction and the latest odds update.  It’s the second of a three-game series at Rogers Centre, and Tuesday’s opener has been excluded from the analysis. The probable starting pitchers for Wednesday are... Read more

An interleague matchup goes down on Wednesday, May 21 as the San Diego Padres take on the Toronto Blue Jays at 7:07 p.m. ET, so continue reading for our Padres vs Blue Jays prediction. This is written before Tuesday's game has ended. Don’t go down on strikes! Get our top Free MLB Picks and increase your bankroll! Padres Swept by SeattleSan Diego enters its three-game series against the Blue Jays on Tuesday and is coming off a three-game sweep at home against the Seattle Mariners. The Padres are... Read more

Get our free Baseball betting pick for the Toronto Blue Jays vs San Diego Padres matchup and gain an edge as a Baseball bettor. Read more

The Blue Jays are -155 favorites vs the Padres Padres vs Blue Jays Over / Under today: 9 Runs Padres / Blue Jays TV Channel: RSN1 | PDTV The San Diego Padres (+125) visit Rogers Centre to take on the Toronto Blue Jays (-155) on Wednesday, May 21, 2025. First pitch is scheduled for 7:07pm EDT in Toronto, ON. This season, the Padres are 27-19 against the spread (ATS), while the Blue Jays are 29-18 ATS. Padres vs Blue Jays Starting Pitchers Today: Padres starting pitcher: Randy Vasquez 3-3, 3.48 ER... Read more

Toronto Blue Jays (23-24) vs San Diego Padres (27-19) Game Info: Wednesday, May 21, 2025 at 7:07 pm (Rogers Centre) R. Vasquez (R) vs K. Gausman (R) Betting Odds: Toronto Blue Jays -155 / San Diego Padres +130 --- Over/Under: 8.5 Click Here for the Latest Odds Where to Watch: MLB.TV The San Diego Padres and the Toronto Blue Jays meet Wednesday in MLB action from Rogers Centre. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs.... Read more