It’s the opening game of a three-game series between NL Central rivals on the diamond in the Gateway City as the Pittsburgh Pirates travel to face the St. Louis Cardinals Monday night and we have you covered with our Pirates vs. Cardinals prediction. Pittsburgh closed out a three-game set at home against the Padres hoping to avoid a sweep. They fell 2-1 in the middle game of the series Saturday night. St. Louis played a doubleheader at home against the Mets Sunday to finish a three-game series.... Read more

The St. Louis Cardinals will host the Pittsburgh Pirates at Busch Stadium and we have you ready to go with the Pirates vs Cardinals prediction. Opening Pitch is slated for 7:45 PM Eastern, and the Pirates have won three of the last four between these two. Read on for the Pirates vs Cardinals prediction and more free MLB picks. Pirates Drop 4 StraightPittsburgh struggled to get going against the Padres, scoring just one run in their final two games of the series. Most recently, they were blanked... Read more

Get our free Baseball betting pick for the St. Louis Cardinals vs Pittsburgh Pirates matchup and gain an edge as a Baseball bettor. Read more

The Cardinals are -145 favorites vs the Pirates Pirates vs Cardinals Over / Under today: 8.5 Runs Pirates / Cardinals TV Channel: FDMW | SNPT The Pittsburgh Pirates (+120) visit Busch Stadium to take on the St. Louis Cardinals (-145) on Monday, May 5, 2025. First pitch is scheduled for 7:45pm EDT in St. Louis, MO. This season, the Pirates are 12-23 against the spread (ATS), while the Cardinals are 17-18 ATS. Pirates vs Cardinals Starting Pitchers Today: Pirates starting pitcher: Carmen Mlodzinsk... Read more

St. Louis Cardinals (16-19) vs Pittsburgh Pirates (12-23) Game Info: Monday, May 5, 2025 at 7:45 pm (Busch Stadium) C. Mlodzinski (R) vs M. Mikolas (R) Betting Odds: St. Louis Cardinals -148 / Pittsburgh Pirates +124 --- Over/Under: 8.5 Click Here for the Latest Odds Where to Watch: MLB.TV In this article we will formulate a Pirates vs Cardinals prediction for this MLB game on Monday, May 5th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.  Pitt... Read more