San Diego Padres (15-6) vs. Detroit Tigers (13-8)  The 2025 Major League Baseball season continues Monday, April 21, with eight games around the big leagues, including the interleague showdown at Comerica Park in Detroit, so we have prepared the best Padres vs. Tigers prediction.   San Diego and Detroit open a three-game series. Last year, the Padres took two out of three games from the Tigers, and San Diego is 4-2 in its previous six contests against Detroit. Read more about this San Diego vs.... Read more

In a Game 1 of an interleague series the Tigers play host to the Padres, so check out the comprehensive San Diego Padres vs. Detroit Tigers prediction. The tigers had their three-game win streak snapped in their last game while the Padres are coming off a win to avoid a series sweep. The first pitch is scheduled for 6:40 pm EST, so continue reading to get all of the full score info and other free MLB picks for the San Diego Padres vs. Detroit Tigers prediction. The Tigers come into Game 1 as a s... Read more

Get our free Baseball betting pick for the Detroit Tigers vs San Diego Padres matchup and gain an edge as a Baseball bettor. Read more

The Tigers are -130 favorites vs the Padres Padres vs Tigers Over / Under today: 8 Runs Padres / Tigers TV Channel: FS1 | PDTV | FDDX The San Diego Padres (+110) visit Comerica Park to take on the Detroit Tigers (-130) on Monday, April 21, 2025. First pitch is scheduled for 6:40pm EDT in Detroit, MI, MI. This season, the Padres are 16-6 against the spread (ATS), while the Tigers are 14-8 ATS. Padres vs Tigers Starting Pitchers Today: Padres starting pitcher: Randy Vasquez 1-1, 1.74 ERA Tigers st... Read more

Detroit Tigers (13-9) vs San Diego Padres (16-6) Game Info: Monday, April 21, 2025 at 6:40 pm (Comerica Park) R. Vasquez (R) vs K. Montero (R) Betting Odds: Detroit Tigers -130 / San Diego Padres +110 --- Over/Under: 8 Click Here for the Latest Odds Where to Watch: FS1 The San Diego Padres and Detroit Tigers meet Monday in MLB action at Comerica Park. Here’s a San Diego Padres vs Detroit Tigers Prediction. This article will include a San Diego Padres vs Detroit Tigers Pick. San Diego Padres Bett... Read more