The Chicago Cubs (11-8, 11-8 RL, 13-5-1 O/U) and the San Diego Padres (14-3, 12-5 RL, 8-8-1 O/U) conclude a three-game series on Wednesday afternoon, and we have the prediction. The Cubs are opting with Matt Boyd. The Padres will counter with the veteran, Nick Pivetta. The season series is 2-2 entering Tuesday.    Can Pivetta continue his dominance for the Padres? Keep reading for the Cubs vs. Padres prediction. Check out the rest of our MLB Picks! Boyd Shines for CubsMatt Boyd will get the nod... Read more

Two of MLB's most explosive lineups clash this Wednesday; get the inside track with our exclusive Cubs vs. Padres prediction and picks. Both Chicago and San Diego have started the season in great shape and lead their respective NL divisions. The first pitch is scheduled to be thrown at 1.10pm PDT (4.10pm EDT) at the Padres' Petco Park home; when it comes to baseball picks, our MLB Predictions are stellar. Cubs on a rollThe Chicago Cubs (11-8) were dealt a tough schedule to open the 2025 MLB seas... Read more

Get our free Baseball betting pick for the San Diego Padres vs Chicago Cubs matchup and gain an edge as a Baseball bettor. Read more

On Wednesday, the Chicago Cubs (11-8) are visiting the San Diego Padres (14-3), at 4:10 p.m. ET. The Padres have taken five straight. The Padres are an underdog (+129 moneyline odds to win) when they take the field at home against the Cubs (-154). The starting pitchers are Matthew Boyd (1-1) for the Chicago Cubs, and Nick Pivetta (2-1) for the San Diego Padres. These clubs meet again after the Padres’ 10-4 victory over the Cubs Monday. Adrian Morejon (1.0 IP, 0 R, 0 H, 1 K) earned the win for th... Read more

San Diego Padres (14-4) vs Chicago Cubs (12-8) Game Info: Wednesday, April 16, 2025 at 4:10 pm (Petco Park) M. Boyd (L) vs N. Pivetta (R) Betting Odds: San Diego Padres -125 / Chicago Cubs +105 --- Over/Under: 7.5 Click Here for the Latest Odds Where to Watch: MLB.TV The Chicago Cubs and the San Diego Padres meet Wednesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. San Diego Padres prediction... Read more