Seattle Mariners (3-4) vs. San Francisco Giants (5-1)  The Seattle Mariners (3-4; 1-5-1 O/U) head to Oracle Park in San Francisco on Friday, April 4, 2025, to square off against the San Francisco Giants (5-1; 4-2 O/U) in the interleague showdown with the first pitch at 4:35 PM ET, and we’ve got you covered with our Mariners vs. Giants prediction.  Seattle and San Francisco open a three-game series. The Giants are slight -115 moneyline favorites with a total of 7.5 runs. Let’s look closer at this... Read more

The Seattle Mariners (3-4) are gearing up to take on the San Francisco Giants (5-1) in interleague action at Oracle Park on Friday afternoon to begin the series as we look at our Mariners vs. Giants prediction. The Mariners are coming off a 3-2 home win on Wednesday against the Detroit Tigers while the Giants are coming off a 6-3 road win against the Houston Astros on Wednesday. Right-hander Luis F. Castillo gets the start for Seattle while veteran righty Justin Verlander pitches for the Giants.... Read more

Get our free Baseball betting pick for the San Francisco Giants vs Seattle Mariners matchup and gain an edge as a Baseball bettor. Read more

The Giants are -160 favorites vs the Mariners Mariners vs Giants Over / Under today: 7.5 Runs Mariners / Giants TV Channel: NSBA | RTNW The Seattle Mariners (+135) visit Oracle Park to take on the San Francisco Giants (-160) on Friday, April 4, 2025. First pitch is scheduled for 4:35pm EDT in San Francisco, CA. This season, the Mariners are 3-4 against the spread (ATS), while the Giants are 6-0 ATS. Mariners vs Giants Starting Pitchers Today: Mariners starting pitcher: Luis Castillo 1-1, 3.00 ER... Read more

On Friday, a series opener is on the schedule, with the San Francisco Giants (5-1) hosting the Seattle Mariners (3-4) at 4:35 p.m. ET. The Mariners are road underdogs (+102) at the Giants (-120). The Giants will give the ball to Justin Verlander versus the Mariners and Bryce Miller (0-1). The Giants beat the Astros by a 6-3 score in their most recent game Wednesday. Luis Matos went 2-for-3 with a home run and an RBI to lead them offensively while Randy Rodriguez picked up the win after throwing... Read more

San Francisco Giants (5-1) vs Seattle Mariners (3-4) Game Info: Friday, April 4, 2025 at 4:35 pm (Oracle Park) L. Castillo (R) vs J. Verlander (R) Betting Odds: San Francisco Giants -155 / Seattle Mariners +130 --- Over/Under: 8 Click Here for the Latest Odds Where to Watch: MLB.TV The Seattle Mariners and the San Francisco Giants meet Friday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Sa... Read more