Cleveland Guardians (2-4) vs. Los Angeles Angels (4-2)  The 2025 MLB betting action goes on Friday, April 4, with the 14-game card, including the interleague showdown at Angel Stadium in Anaheim, CA, with the first pitch at 9:38 PM ET, so we’ve prepared the best Guardians vs. Angels prediction.    Cleveland and Los Angeles open a three-game series in California. The Guardians are listed as -120 moneyline favorites with a total of 7.5 runs. Read more about our Cleveland vs. Los Angeles prediction... Read more

The MLB season is starting to take shape, and at this point of the year every matchup is fun, and now we look at another with the Cleveland Guardians vs. Los Angeles Angels prediction. The Cleveland Guardians (2-4) have high expectations coming into 2025 after winning the division three of the last four years, but after two poor series, they'll need to turn it around in their third straight road series. On Friday that begins against the Los Angeles Angels (4-2), a team that are always overlooked... Read more

Get our free Baseball betting pick for the Los Angeles Angels vs Cleveland Guardians matchup and gain an edge as a Baseball bettor. Read more

A series opener between the Cleveland Guardians (2-4) and Los Angeles Angels (4-2) is on deck Friday at 9:38 p.m. ET, at Angel Stadium. The Guardians are favored (-120 on the moneyline to win) when they take on the Angels (+101). The matchup on the mound for this contest is set with the Cleveland Guardians looking to Gavin Williams, and Jose Soriano (1-0) taking the ball for the Los Angeles Angels. The Guardians lost 5-2 to the Padres Wednesday, with Ben Lively (4 1/3 innings, giving up four ear... Read more

Los Angeles Angels (4-2) vs Cleveland Guardians (2-4) Game Info: Friday, April 4, 2025 at 9:38 pm (Angel Stadium) G. Williams (R) vs J. Soriano (R) Betting Odds: Los Angeles Angels -105 / Cleveland Guardians -115 --- Over/Under: 7.5 Click Here for the Latest Odds Where to Watch: MLB.TV The Cleveland Guardians and Los Angeles Angels meet Friday in MLB action at Angel Stadium. Here’s a Cleveland Guardians vs Los Angeles Angels Prediction. This article will include a Cleveland Guardians vs Los Ange... Read more